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<p class="ql-align-justify">1- Duodenal mucosa show focal moderate villous atrophy associated i<span style="color: rgb(0, 29, 53);">ntraepithelial lymphocytosis and crypt hyperplasia </span>malignancwith submucosal mild infiltrate of lymphocytes and plasma cells. No evidence of specific granulomas. No evidence of atypia or malignancy.</p><p class="ql-align-justify">2- Intact colonic mucosa mildly infiltrated by lymphocytes and plasma cells with lymphoid follicles. Some Neutrophils are seen infiltrating glands this indicating activity, but there is no evidence of crypt abscesses. Mucigenic cells are mildly decreased. No evidence of atypia or malignancy.</p>
<p class="ql-align-justify">Known Celiac disease presented for an endoscopy that revealed mucosal fissuring in the second part of the duodenum.</p>
<p>Two biopsies were received:</p><p class="ql-align-justify">1- Duodenum: soft tissue fragments collectively measured 0.7 cm, totally embedded.</p><p class="ql-align-justify">2- Colon: soft tissue fragments collectively measured 0.7 cm, totally embedded.</p>
<h3><strong><em><u>1- Duodenum, endoscopic biopsy:</u></em></strong></h3><ul><li><strong>Focal moderate villous atrophy with associated chronic non-specific duodenitis, consistent with celiac disease. </strong></li><li><strong>Modified Marsh-Oberhuber classification, grade 3a (</strong><strong style="color: oklch(0.2642 0.013 93.9); background-color: oklch(0.9798 0.005 78.3);">Corazza & Villanacci </strong><strong>grade B1).</strong></li><li><strong>Negative for malignancy. </strong></li></ul><p><br></p><p><strong><em><u>2- Colon, endoscopic biopsy: </u></em></strong></p><ul><li><strong>Mild chronic follicular colitis with mild inflammatory activity. </strong></li><li><strong>Negative for dysplasia and malignancy. </strong></li></ul>
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