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<p class="ql-align-justify">Intact rectal mucosa mildly infiltrated by lymphocytes and plasma cells. There is complete absence of ganglion cells of the submucosal plexus (Meissner's plexus). There is associated moderate hypertrophy of nerves. Picture is consistent with aganglionic segment (Hirschsprung's disease). No evidence of atypia or malignancy.</p>
<p>Suspected Hirschsprung disease.</p>
<p class="ql-align-justify">Rectal fragment measured 2.5x2x1.5 cm, totally embedded.</p>
<p><strong><em><u>Rectum, Biopsy: </u></em></strong></p><ul><li><strong>Aganglionic segment (Hirschsprung's disease) with nerve bundles hypertrophy.</strong></li><li><strong>Negative for malignancy </strong></li></ul>
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